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One study in six subjects demonstrated that the combination of furosemide and acetylsalicylic acid temporarily reduced creatinine clearance in patients with chronic renal insufficiencyThere are case reports of patients who developed increased BUNserum creatinine and serum potassium levelsand weight gain when furosemide was used in conjunction with NSAIDs.

Hepatic encephalopathy in patients with hepatocellular insufficiency pancreatitis jaundiceintrahepatic cholestatic jaundiceincreased liver enzymes anorexia oral and gastric irritation cramping diarrhea constipation nausea vomiting.

Patients receiving LASIX should be advised that they may experience symptoms from excessive fluid and/or electrolyte lossesThe postural hypotension that sometimes occurs can usually be managed by getting up slowlyPotassium supplements and/or dietary measures may be needed to control or avoid hypokalemia.

Treatment of overdosage is supportive and consists of replacement of excessive fluid and electrolyte lossesSerum electrolytescarbon dioxide level and blood pressure should be determined frequentlyAdequate drainage must be assured in patients with urinary bladder outlet obstructionsuch as prostatic hypertrophy

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